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KMID : 0870519980020010014
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Journal of Korean Academy of Addiction Psychiatry
1998 Volume.2 No. 1 p.14 ~ p.21
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Effects of Combination Therapy with Fluoxetine and Alcoholics Treatment Program on Alcohol Craving
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Park Jeong-Rae
Lee Sang-Ick
Chung In-Won
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Abstract
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longterm period abstinence. One of main relapsing factors is alcohol craving. This study is to investigate the efficacy of
combination therapy with fluoxetine and psychosocial treatment (Alcoholics Treatment Program) on alcohol craving. The subjects were twenty male alcoholics recovered from acute alcohol intoxication and withdrawal symptoms. They were randomly assigned to combined treatment group or psychosocial treatment group. Each group consists of 10 patients, and received psychosocial treatment program for four weeks. The patients in combined treatment group were administered fluoxetine with fixed dose 60 mg/day and the patients in psychosocial treatment group were administered placebo for four weeks. Alcohol craving was measured by Visual Analogue Scale (VAS), Verbal Rating Scalem (VRS) and the amount of alcohol intake at the baseline, first week, second week and fourth week during the treatment. Mood status also measured by Hamilton Depression Rating Scale (HDRS) at the same time. In combined treatment group, the changes in alcohol craving measured by VAS and VRS was significantly reduced at the second and fourth week, however, depressed mood was different only at fourth week in comparison with psychosocial treatment group. No differences were noted in alcohol craving measured by amount of alcohol intake between two groups. These results show that adjunctive administration of fluoxetine to psychosocial treatment more rapidly reduced alcohol craving than psychosocial treatment only and the effects was not due to improvement of depression. Thus, the combination therapy may be an effective treatment strategy for prevention of relapse in alcoholics.
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KEYWORD
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Alcoholism, Combination therapy, Psychosocial treatment, Fluoxetine
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